Nav1.8 inhibitor 42

Chemical Structure : Nav1.8 inhibitor 42

Catalog No.: PC-23587Not For Human Use, Lab Use Only.

Nav1.8 inhibitor 42 is a potent, selective Nav1.8 inhibitor with IC50 of 35 nM (human Nav1.8), shows weak actiivty against mouse Nav1.8 (IC50=3040 nM).

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Biological Activity

Nav1.8 inhibitor 42 is a potent, selective Nav1.8 inhibitor with IC50 of 35 nM (human Nav1.8), shows weak actiivty against mouse Nav1.8 (IC50=3040 nM).
Nav1.8 inhibitor 42 shows no activity against a broad panel of GPCRs, enzymes, and other ion channels.

Physicochemical Properties

M.Wt	521.41
Formula	C21H14F7N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-fluoro-2-(trifluoromethyl)phenoxy)-N-(3-(S-methylsulfonimidoyl)phenyl)-5-(trifluoromethyl)nicotinamide

References

1. Poslusney M, et al. Bioorg Med Chem Lett. 2024 Dec 5:130059.

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