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Chemical Structure : Navitoclax
CAS No.: 923564-51-6
Catalog No.: PC-42277Not For Human Use, Lab Use Only.
Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $348 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.
Navitoclax (ABT-263) binds more weakly to Mcl-1 and A1 (Ki>350 nM).
Navitoclax (ABT-263) disrupts Bcl-2/Bcl-xL interactions with pro-death proteins (e.g., Bim), induces apoptosis, shows cellular activity against a panel of human tumor cell lines (EC50<1 uM).
Navitoclax (ABT-263) induces complete tumor regressions in xenograft models of NSCLA and ALL.
| M.Wt | 974.6127 | |
| Formula | C47H55ClF3N5O6S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]- |
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1. Tse C, et al. Cancer Res. 2008 May 1;68(9):3421-8.
2. Shoemaker AR, et al. Clin Cancer Res. 2008 Jun 1;14(11):3268-77.
3. Ackler S, et al. Mol Cancer Ther. 2008 Oct;7(10):3265-74.
4. Shah OJ, et al. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12634-9.
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