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Nebentan

Chemical Structure : Nebentan

CAS No.: 342005-82-7

Nebentan (YM598, Nebentan potassium)

Catalog No.: PC-28489Not For Human Use, Lab Use Only.

Nebentan (Nebentan potassium, YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist, inhibits [125I] endothelin-1 binding to cloned human ETA receptor with Ki of 0.697 nM, >800-fold selective over ETB receoptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nebentan (Nebentan potassium, YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist, inhibits [125I] endothelin-1 binding to cloned human ETA receptor with Ki of 0.697 nM, >800-fold selective over ETB receoptor.

Physicochemical Properties

M.Wt 529.61
Formula C24H20KN5O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

potassium (E)-(6-methoxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)(styrylsulfonyl)amide

References

1. Hironori Yuyama, et al. Eur J Pharmacol. 2003 Sep 30;478(1):61-71.

2. Akira Fujimori, et al.J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S354-7.

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