Nebicapone |CAS:274925-86-9 Probechem Biochemicals

Chemical Structure : Nebicapone

CAS No.: 274925-86-9

Nebicapone (BIA 3-202;BIA3-202)

Catalog No.: PC-35791Not For Human Use, Lab Use Only.

Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7 nM for rat brain COMT, much less potent for liver COMT with IC50 of 696 nM.

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Biological Activity

Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7 nM for rat brain COMT, much less potent for liver COMT with IC50 of 696 nM.
Nebicapone (BIA 3-202, BIA3-202) enhances the availability of L-DOPA to the brain and reduces its O-methylation.
Nebicapone (BIA 3-202, BIA3-202) is an adjunct to levodopa/carbidopa or levodopa/benserazide in the treatment of Parkinson's disease.

Physicochemical Properties

M.Wt	273.244
Formula	C14H11NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethan-1-one

References

1. Parada A, et al. Pharmacology. 2003 May;68(1):29-37.

2. Bonifácio MJ, et al. Eur J Pharmacol. 2003 Jan 24;460(2-3):163-70.

3. Learmonth DA, et al. J Med Chem. 2002 Jan 31;45(3):685-95.

4. Parada A, et al. Eur J Pharmacol. 2001 May 18;420(1):27-32.

Nebicapone (BIA 3-202;BIA3-202)

Biological Activity

Physicochemical Properties

References

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