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Nec-1s

Chemical Structure : Nec-1s

CAS No.: 852391-15-2

Nec-1s (7-Cl-O-Nec1, Necrostatin 1S, Necrostatin 2 racemate)

Catalog No.: PC-22669Not For Human Use, Lab Use Only.

Nec-1s (7-Cl-O-Nec-1) is an optimized derivative of Nec-1 and potent, specific necroptosis inhibitor with EC50 of 210 nM in Jurkat cells, exhibits the protection in an ischemic brain injury model, selectively inhibits RIPK1 and lacks activity against IDO.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nec-1s (7-Cl-O-Nec-1) is an optimized derivative of Nec-1 and potent, specific necroptosis inhibitor with EC50 of 210 nM in Jurkat cells, exhibits the protection in an ischemic brain injury model, selectively inhibits RIPK1 and lacks activity against IDO.

Physicochemical Properties

M.Wt 277.71
Formula C13H12ClN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione

References

1. Degterev A, et al. Nat Chem Biol. 2005 Jul;1(2):112-9.

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