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Chemical Structure : Necrostatin-34
CAS No.: 375835-43-1
Catalog No.: PC-73007Not For Human Use, Lab Use Only.
Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM.
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|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
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| 100 mg | Get quote |
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Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM.
Nec-34 effectively inhibited necroptosis induced by the addition of AP20187 and zVAD.fmk, inhibited the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation.
Nec-34 showed no effect on the early activation signatures of NF-κB and MAPK pathways, including phosphorylation of IKKα/β, p65, p38, JNK, MK2, IκBα, and degradation of IκBα.
Nec-34 inhibited the activity of RIPK1 (IC50=5.5 uM, 111 mM ATP) and disrupted the formation of complex II.
Nec-34 inhibits RIPK1 kinase through a mechanism distinct from that of Nec-1s.
| M.Wt | 384.48 | |
| Formula | C18H16N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide |
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1. Huyan Meng, et al. Cell Discov. 2021 Jun 1;7(1):41.
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