Ned 19 | NAADP inhibitor | Probechem Biochemicals

Chemical Structure : Ned 19

CAS No.: 874374-25-1

Catalog No.: PC-62183Not For Human Use, Lab Use Only.

Ned 19 is a chemical probe inhibitor for the Ca(2+)-releasing second messenger NAADP, blocks NAADP signaling with IC50 of 65 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ned 19 is a chemical probe inhibitor for the Ca(2+)-releasing second messenger NAADP, blocks NAADP signaling with IC50 of 65 nM.

Ned 19 blocks NAADP signaling and fluorescently labeled NAADP receptors in intact cells.

Ned 19 antagonizes NAADP-activation of TPC2 in a non-competitive manner at 1 uM.

M.Wt	514.59
Formula	C30H31FN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

1. Naylor E, et al. Nat Chem Biol. 2009 Apr;5(4):220-6.