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Ned 19

Chemical Structure : Ned 19

CAS No.: 874374-25-1

Ned 19 (NAADP inhibitor Ned 19)

Catalog No.: PC-62183Not For Human Use, Lab Use Only.

Ned 19 is a chemical probe inhibitor for the Ca(2+)-releasing second messenger NAADP, blocks NAADP signaling with IC50 of 65 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ned 19 is a chemical probe inhibitor for the Ca(2+)-releasing second messenger NAADP, blocks NAADP signaling with IC50 of 65 nM.
Ned 19 blocks NAADP signaling and fluorescently labeled NAADP receptors in intact cells.
Ned 19 antagonizes NAADP-activation of TPC2 in a non-competitive manner at 1 uM.

 

Physicochemical Properties

M.Wt 514.59
Formula C30H31FN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

References

1. Naylor E, et al. Nat Chem Biol. 2009 Apr;5(4):220-6.

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