Catalog No.: PC-62456Not For Human Use, Lab Use Only.
Nef-IN-B9 (Hck inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM.
Nef-IN-B9 (Hck inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM.
Nef-IN-B9 (Hck inhibitor B9) also showes weak activity against other Src-family members with IC50 of >20 uM for c-Src, Lck and Lyn.
Nef-IN-B9 (Hck inhibitor B9) blocks wild-type HIV-1 replication with IC50 of 100-300 nM, and blocks Nef-mediated SFK activation in HIV-infected cells.
Nef-IN-B9 (Hck inhibitor B9) binds directly to Nef with Kd of 1.79 nM.
