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Nelociguat

Chemical Structure : Nelociguat

CAS No.: 625115-52-8

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Nelociguat (BAY60-4552, BAY 60-4552)

Catalog No.: PC-45991Not For Human Use, Lab Use Only.

Nelociguat (BAY60-4552) is a direct soluble guanylate cyclase (sGC) stimulator that acts independently of nitric oxide (NO).

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10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nelociguat (BAY60-4552) is a direct soluble guanylate cyclase (sGC) stimulator that acts independently of nitric oxide (NO).
Nelociguat (BAY60-4552) has an EC50 of 353 nM on P-VASP formation in rat aortic smooth muscle cells.

Physicochemical Properties

M.Wt 408.3891
Formula C19H17FN8O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 105 mg/mL (Need ultrasonic)

Chemical Name/SMILES

Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester

References

1. Costell MH, et al. Front Pharmacol. 2012 Jul 5;3:128.

2. Oudot A, et al. Eur Urol. 2011 Nov;60(5):1020-6.

3. Albersen M, et al. J Sex Med. 2013 May;10(5):1268-77.

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