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Nelonicline

Chemical Structure : Nelonicline

CAS No.: 1026134-63-3

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Nelonicline (ABT-126;ABT126)

Catalog No.: PC-35624Not For Human Use, Lab Use Only.

Nelonicline (ABT-126) is a potent, selective α7 nicotinic receptor (nAChR) partial agonist for the treatment of cognitive impairment with schizophrenia..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Nelonicline (ABT-126) is a potent, selective α7 nicotinic receptor (nAChR) partial agonist for the treatment of cognitive impairment with schizophrenia.

Alzheimer Disease

Phase 2 Clinical

Physicochemical Properties

M.Wt 312.431
Formula C18H20N2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((5S,7S)-adamantan-2-yl)oxy)-5-phenyl-1,3,4-thiadiazole

References

1. Gault LM, et al. Alzheimers Dement (N Y). 2015 Jun 23;1(1):81-90.

2. Hashimoto K. Curr Pharm Des. 2015;21(26):3797-806.

3. Zhang D, et al. Mov Disord. 2015 Dec;30(14):1901-1911.

4. Haig G, et al. Neuropsychopharmacology. 2016 Nov;41(12):2893-2902.

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