Nelotanserin (RVT-102, APD125) | 5-HT2A antagonist

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Chemical Structure : Nelotanserin

CAS No.: 839713-36-9

Nelotanserin (APD-125, RVT-102, APD125, RVT102)

Catalog No.: PC-42651Not For Human Use, Lab Use Only.

Nelotanserin (RVT-102, APD125) is a potent, selective 5-HT2A inverse agonist with pKi of 9.2.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nelotanserin (RVT-102, APD125) is a potent, selective 5-HT2A inverse agonist with pKi of 9.2.
Nelotanserin displays >30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors.
Nelotanserin prevents DOI-induced hypolocomotion and increases sleep consolidation; orally active.

Physicochemical Properties

M.Wt	437.2381
Formula	C18H15BrF2N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	Urea, N-[3-(4-bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-N'-(2,4-difluorophenyl)-

References

1. Teegarden BR, et al. J Med Chem. 2010 Mar 11;53(5):1923-36.

2. Al-Shamma HA, et al. J Pharmacol Exp Ther. 2010 Jan;332(1):281-90.

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Nelotanserin (APD-125, RVT-102, APD125, RVT102)

Biological Activity

Physicochemical Properties

References

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