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Nesuparib

Chemical Structure : Nesuparib

CAS No.: 2055357-64-5

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Nesuparib (JPI-547, NOV140201)

Catalog No.: PC-73432Not For Human Use, Lab Use Only.

Nesuparib (JPI-547, NOV140201) is a potent, oral, dual inhibitor of PARP 1/2 and Tankyrase 1/2, demonstrates anti-tumor activity in BRCA-deficient cancer.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nesuparib (JPI-547, NOV140201) is a potent, oral, dual inhibitor of PARP 1/2 and Tankyrase 1/2, demonstrates anti-tumor activity in BRCA-deficient cancer.
Nesuparib (JPI-547, NOV140201) shows anti-tumor activity in BRCA-deficient xenograft models as a single-agent and in combination with chemotherapy and immune checkpoint inhibitors.

Physicochemical Properties

M.Wt 400.486
Formula C23H24N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Pyridinecarbonitrile, 6-[4-[(1,2,3,4,5,6-hexahydro-5-oxobenzo[h]-1,6-naphthyridin-8-yl)methyl]-1-piperazinyl]-

References

1. Seock-Ah Im, et al. 2021 ASCO Annual Meeting I.

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