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Nevirapine

Chemical Structure : Nevirapine

CAS No.: 129618-40-2

Nevirapine (BI-RG 587;NSC 641530;NVP)

Catalog No.: PC-42657Not For Human Use, Lab Use Only.

A potent and specific non-nucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 0.2 uM.

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Biological Activity

Nevirapine (BI-RG 587, NSC 641530) is a potent and specific non-nucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 0.2 uM.
Nevirapine shows no effect on feline and simian RT or any mammalian DNA polymerases.
Nevirapine inhibits HIV-1 replication and protein p24 production.

Physicochemical Properties

M.Wt 266.2979
Formula C15H14N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-

References

1. Merluzzi VJ, et al. Science. 1990 Dec 7;250(4986):1411-3.

2. Cohen KA, et al. J Biol Chem. 1991 Aug 5;266(22):14670-4.

3. Richman D, et al. Antimicrob Agents Chemother. 1991 Feb;35(2):305-8.

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