Chemical Structure : Nexatoclax
CAS No.:
2290611-27-5
Nexatoclax
(LP-118, LP118)
Catalog No.: PC-26343Not For Human Use, Lab Use Only.
Nexatoclax (LP-118) is a potent small molecule inhibitor of Bcl-2 and Bcl-xL (IC50=10.1 nM), more potent than venetoclax and with added advantage of selectively binding to Bcl-xL while minimizing the platelet toxicity.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Nexatoclax (LP-118) is a potent small molecule inhibitor of Bcl-2 and Bcl-xL (IC50=10.1 nM), more potent than venetoclax and with added advantage of selectively binding to Bcl-xL while minimizing the platelet toxicity.
Nexatoclax (LP-118) shows IC50 of 0.5 nM for naive CLL cells, more sensitive to LP-118 than venetoclax and navitoclax.
Nexatoclax (LP-118) has IC50 of 20 nM for RS4; 11 cells harboring the Bcl-2 Gly101Val mutation.
Nexatoclax (LP-118) (100 mpk, oral gavage, daily) significantly decreases overall tumor growth and increases survival in RS4; 11 xenograft model.
Physicochemical Properties
|
M.Wt
|
925.50
|
|
Formula
|
C47H53ClN8O8S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3-nitrophenyl)sulfonyl)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-2-(3,4-dihydro-2H-pyrrolo[3',2':5,6]pyrido[2,3-b][1,4]oxazepin-1(7H)-yl)benzamide
|
References
1. Patent WO2021173523 A1.
2. Patent WO2021066873 A1.
3. Janani Ravikrishnan, et al. Blood (2021) 138 (Supplement 1): 679.
Contact Us
sales@probechem.com
