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Chemical Structure : Nifuroxazide
CAS No.: 965-52-6
Catalog No.: PC-49691Not For Human Use, Lab Use Only.
Nifuroxazide (NFX) is a broad-spectrum antibacterial agent, also exhibits potent inhibition of the transcription factor STAT3, also inhibits ERG-mediated transcription, is selectively bio-activated by ALDH1 enzymes over ALDH2 enzymes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 250 mg | $198 | In stock | |
| 1 g | $328 | In stock | |
| 5 g | Get quote |
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Nifuroxazide (NFX) is a broad-spectrum antibacterial agent, also exhibits potent inhibition of the transcription factor STAT3, also inhibits ERG-mediated transcription, is selectively bio-activated by ALDH1 enzymes over ALDH2 enzymes.
Nifuroxazide inhibited the proliferation of a TMPRSS2:ERG fusion-positive prostate cancer cell line (VCaP) with an IC50 lower than that of ERG-negative prostate cancer cell lines (LNCaP, DU145 and WPMY cells).
Nifuroxazide blcoked PARP1 interaction with ERG, which is required for ERG-mediated transcription.
Nifuroxazide inhibited survival of multiple myeloma cells by directly inhibiting STAT3, inhibited STAT3-dependent luciferase activity with EC50 of 3 uM.
Nifuroxazide selectively eradicates ALDH1High melanoma tumor-initiating cells.
| M.Wt | 275.22 | |
| Formula | C12H9N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-hydroxy-benzoic acid, 2-[(5-nitro-2-furanyl)methylene]hydrazide |
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1. Li C, et al. Mol Cancer Ther. 2023 Jan 9:MCT-22-0159.
2. Ye TH, et al. Cell Death Dis. 2017 Jan 5;8(1):e2534.
3. Nelson EA, et al. Blood. 2008 Dec 15;112(13):5095-102.
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