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Chemical Structure : Nigericin
CAS No.: 28380-24-7
Catalog No.: PC-22728Not For Human Use, Lab Use Only.
Nigericin (NSC 292567) is an ionophore antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Nigericin (NSC 292567) is an ionophore antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes.
Nigericin sodium is a research tool to disrupt intracellular H+ and K+ concentration, thus altering pH, membrane potential, and cell volum。
Nigericin sodium inhibits the Golgi functions in Eukaryotic cells.
Nigericin sodium is the canonical NLRP3 inflammasome agonist.
| M.Wt | 724.97 | |
| Formula | C40H68O11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-3-methyltetrahydro-2H-pyran-2-yl)propanoic acid |
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1. Gray MA, et al. Eur J Biochem. 1983 Sep 15;135(2):299-302.
2. Tartakoff AM, et al. J Exp Med. 1977 Nov 1;146(5):1332-45.
3. Zotova L, et al. J Biol Chem. 2010 May 7;285(19):14399-414.
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