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Chemical Structure : Nigericin sodium
CAS No.: 28643-80-3
Catalog No.: PC-42123Not For Human Use, Lab Use Only.
Nigericin sodium (NSC 292567) is an ionophore antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Nigericin sodium (NSC 292567) is an ionophore antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes.
Nigericin sodium is a research tool to disrupt intracellular H+ and K+ concentration, thus altering pH, membrane potential, and cell volum。
Nigericin sodium inhibits the Golgi functions in Eukaryotic cells.
Nigericin sodium is the canonical NLRP3 inflammasome agonist.
| M.Wt | 746.9432 | |
| Formula | C40H67NaO11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in ethanol; DMSO: < 0.3 mg/mL; H2O: < 0.3 mg/mL |
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| Chemical Name/SMILES |
Nigericin, sodium salt (1:1) |
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1. Gray MA, et al. Eur J Biochem. 1983 Sep 15;135(2):299-302.
2. Zotova L, et al. J Biol Chem. 2010 May 7;285(19):14399-414.
3. Tartakoff AM, et al. J Exp Med. 1977 Nov 1;146(5):1332-45.
4. Boesch M, et al. Stem Cells Transl Med. 2015 Sep;4(9):1028-32.
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