Nilotinib (AMN107) | BCR-ABL1 inhibitor

Chemical Structure : Nilotinib

CAS No.: 641571-10-0

Nilotinib (AMN-107, Tasigna, AMN107)

Catalog No.: PC-42407Not For Human Use, Lab Use Only.

Nilotinib (AMN107) is a potent, selective, orally available inhibitor of both native and mutant Bcr-Abl with IC50 of 20-80 nM.

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100 mg	$78	In stock
500 mg	$158	In stock
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Biological Activity

Nilotinib (AMN107) is a potent, selective, orally available inhibitor of both native and mutant Bcr-Abl with IC50 of 20-80 nM.
Nilotinib (AMN-107) inhibits proliferation of Ba/F3 cells expressing G250E, E255K(V), F317L, M351T, F486S, M244V, L248R, Q252H, Y253H, E255K, E279K, E282D, V289S, and L348M Bcr-Abl mutants at <1 uM.
Nilotinib (AMN-107) also inhibits activated forms of PDGFR and c-Kit with IC50 of 30-200 nM.
Nilotinib (AMN-107) prolongs survival of mice with leukemia due to imatinib-resistant mutants of Bcr-Abl.

Physicochemical Properties

M.Wt	529.5158
Formula	C28H22F3N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 28 mg/mL
Chemical Name/SMILES	Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-

References

1. Weisberg E, et al. Cancer Cell. 2005 Feb;7(2):129-41.

2. O'Hare T, et al. Cancer Res. 2005 Jun 1;65(11):4500-5.

3. Golemovic M, et al. Clin Cancer Res. 2005 Jul 1;11(13):4941-7.

4. Stover EH, et al. Blood. 2005 Nov 1;106(9):3206-13.

Nilotinib (AMN-107, Tasigna, AMN107)

Biological Activity

Physicochemical Properties

References

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