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Chemical Structure : Nilotinib monohydrochloride monohydrate
CAS No.: 923288-90-8
Catalog No.: PC-42408Not For Human Use, Lab Use Only.
A potent, selective, orally available inhibitor of both native and mutant Bcr-Abl with IC50 of 20-80 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 200 mg | $49.6 | In stock | |
| 500 mg | $96 | In stock |
Bulk size, bulk discount!
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A potent, selective, orally available inhibitor of both native and mutant Bcr-Abl with IC50 of 20-80 nM; inhibits proliferation of Ba/F3 cells expressing G250E, E255K(V), F317L, M351T, F486S, M244V, L248R, Q252H, Y253H, E255K, E279K, E282D, V289S, and L348M Bcr-Abl mutants at <1 uM; also inhibits activated forms of PDGFR and c-Kit with IC50 of 30-200 nM; prolongs survival of mice with leukemia due to imatinib-resistant mutants of Bcr-Abl.
Blood Cancer
Approved
| M.Wt | 583.992 | |
| Formula | C28H25ClF3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-, hydrochloride, hydrate (1:1:1) |
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1. Weisberg E, et al. Cancer Cell. 2005 Feb;7(2):129-41.
2. O'Hare T, et al. Cancer Res. 2005 Jun 1;65(11):4500-5.
3. Golemovic M, et al. Clin Cancer Res. 2005 Jul 1;11(13):4941-7.
4. Stover EH, et al. Blood. 2005 Nov 1;106(9):3206-13.
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