Nimbolide

Chemical Structure : Nimbolide

CAS No.: 25990-37-8

Catalog No.: PC-21374Not For Human Use, Lab Use Only.

Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping.

Packing	Price	Stock
5 mg	$218	In stock
10 mg	$358	In stock
25 mg	$588	In stock
50 mg		Get quote
100 mg		Get quote

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Biological Activity

Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping.
Nimbolide treatment is synthetically lethal in BRCA-deficient tumor cells.
Nimbolide is also able to kill BRCA-deficient tumor cells with intrinsic and acquired resistance to conventional PARPi.
Nimbolide has significant bactericidal activity against H. pylori, killing both free living bacterial cells as well as cells within a biofilm.
Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling.

Physicochemical Properties

M.Wt	466.53
Formula	C27H30O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate

References

1. Li P, et al. Sci Adv. 2023 Oct 27;9(43):eadg7752.

2. Mehmetoglu-Gurbuz T, et al. Antioxidants (Basel). 2023 Sep 22;12(10):1791.

3. Wylie MR, et al. J Ethnopharmacol. 2022 Mar 1;285:114828.

Nimbolide

Biological Activity

Physicochemical Properties

References

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