Nimesulide | COX-2 inhibitor | Probechem Biochemicals

Chemical Structure : Nimesulide

CAS No.: 51803-78-2

Nimesulide (R805, R-805)

Catalog No.: PC-28646Not For Human Use, Lab Use Only.

Nimesulide (R705) is a non-steroid anti-inflammatory agent and selective COX-2 inhibitor with IC50s of 70 nM-70 μM in a time-dependent manner, shows no effect on COX-1 (IC50 >100 μM), exhibits potent anti-inflammatory, analgesic and antipyretic properties.

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Biological Activity

Nimesulide (R805) is a non-steroid anti-inflammatory agent and selective COX-2 inhibitor with IC50s of 70 nM-70 μM in a time-dependent manner, shows no effect on COX-1 (IC50 >100 μM), exhibits potent anti-inflammatory, analgesic and antipyretic properties.

Physicochemical Properties

M.Wt	308.31
Formula	C13H12N2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

References

1. Vago T, et al. Arzneimittelforschung. 1995 Oct;45(10):1096-8.

2. Werner MF, et al. Eur J Pharmacol. 2006 Aug 14;543(1-3):181-9.

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Nimesulide (R805, R-805)

Biological Activity

Physicochemical Properties

References

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