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Chemical Structure : Niraxostat
CAS No.: 206884-98-2
Catalog No.: PC-20359Not For Human Use, Lab Use Only.
Niraxostat (Y-700) is a potent, long-lasting, orally effective xanthine oxidase (XO) inhibitor with IC50 of 5.8 nM, exhibits potent and long-lasting hypouricemic effect in rat model of hyperuricemia.
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Niraxostat (Y-700) is a potent, long-lasting, orally effective xanthine oxidase (XO) inhibitor with IC50 of 5.8 nM, exhibits potent and long-lasting hypouricemic effect in rat model of hyperuricemia.
Niraxostat (Y-700) binds tightly both to the active sulfo-form and to the inactive desulfo-form of the enzyme with K(d) values of 0.9 and 2.8 nM, respectively.
Y-700 (1-10 mg/kg, oral) dose dependently lowered plasma urate levels in oxonate-treated rats.
Y-700 (0.3-3 mg/kg) dose dependently reduced the urinary excretion of urate and allantoin in normal rats.
| M.Wt | 299.33 | |
| Formula | C16H17N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid |
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1. S Ishibuchi, et al. Bioorg Med Chem Lett. 2001 Apr 9;11(7):879-82.
2. Fukunari A, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):519-28.
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