Catalog No.: PC-49553Not For Human Use, Lab Use Only.
Nitazoxanide (NTX) is a thiazolide anti-infective agent that efficiently inhibits the HBV regulatory protein X (HBx)-DDB1 protein interaction, exhibits potent inhibition of both HBV and HCV replication.
Nitazoxanide (NTX) is a thiazolide anti-infective agent that efficiently inhibits the HBV regulatory protein X (HBx)-DDB1 protein interaction, exhibits potent inhibition of both HBV and HCV replication.
Nitazoxanide significantly restores Smc5 protein levels and suppresses viral transcription and viral protein production in the HBV minicircle system and in human primary hepatocytes naturally infected with HBV.
Nitazoxanide is active against anaerobic bacteria, protozoa, and a range of viruses in cell culture model.
Nitazoxanide is equally effective at inhibiting replication of lamivudine (LMV) and adefovir dipovoxil (ADV)-resistant HBV mutants and against 2'-C-methyl cytidine (2'CmeC) and telaprevir (VX-950)-resistant HCV mutants.
Nitazoxanide displayed synergistic interactions with LMV or ADV against HBV, and with recombinant interferon alpha-2b (IFN) or 2'CmeC against HCV.
Physicochemical Properties
M.Wt
307.28
Formula
C12H9N3O5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-benzamide
References
1. Korba BE, et al. Antiviral Res. 2008 Jan;77(1):56-63.
2. Keeffe EB, et al. World J Gastroenterol. 2009 Apr 21;15(15):1805-8.
3. Sekiba K, et al. Cell Mol Gastroenterol Hepatol. 2019;7(2):297-312.
4. Sekiba K, et al. J Hepatol. 2022 Jan;76(1):53-62.
