Nivegacetor | γ-secretase modulator | Probechem Biochemicals

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Chemical Structure : Nivegacetor

Nivegacetor (RG6289, RG-6289)

Catalog No.: PC-24970Not For Human Use, Lab Use Only.

Nivegacetor (RG6289) is a novel, potent and selective, orally bioavailable γ-secretase modulator (GSM), induces a dose‐dependent shift in the production of longer (Aβ40 and Aβ42) and shorter (Aβ37 and Aβ38) Aβ monomers in serial cerebrospinal fluid (CSF).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	469.50
Formula	C23H25F2N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-7-(3,5-difluorophenoxy)-N-((1R,5S,8s)-3-(6-methoxypyridazin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine

References

1. Thomas Mueggler, et al. Alzheimers Dement. 2025 Jan 9;20(Suppl 8):e095213.

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Nivegacetor (RG6289, RG-6289)

Biological Activity

Physicochemical Properties

References

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