Catalog No.: PC-72336Not For Human Use, Lab Use Only.
No. 10-3 (PSF inhibitor No. 10-3) is a small molecule that inhibits RNA binding by PSF with IC50 of 2.2 pM (nhibiting the interaction of PSF with CTBP1-AS probe), decreases prostate cancer cell viability (22Rv1 cells IC50=1.2 uM).
No. 10-3 (PSF inhibitor No. 10-3) is a small molecule that inhibits RNA binding by PSF with IC50 of 2.2 pM (nhibiting the interaction of PSF with CTBP1-AS probe), decreases prostate cancer cell viability (22Rv1 cells IC50=1.2 uM).
No. 10-3 inhibited the PSF-mediated RNA splicing and the epigenetic pathway that promotes apoptosis and inhibits cell cycle in both breast and prostate cancer cells.
Pharmacologic inhibition of PSF function by No. 10-3 impaired tumor growth in a xenograft mouse model of treatment-resistant prostate cancer.
RNA-binding protein PSF functions as an epigenetic modifier by interacting with long noncoding RNAs and the corepressor complex. PSF also promotes RNA splicing events to enhance oncogenic signals.
Physicochemical Properties
M.Wt
284.267
Formula
C16H12O5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
7,8-dihydroxy-4-(4-methoxyphenyl)chromen-2-one
References
1. Ken-Ichi Takayama, et al. Cancer Res. 2021 Jul 1;81(13):3495-3508.
