Chemical Structure : Nordihydroguaiaretic acid
CAS No.:
500-38-9
Nordihydroguaiaretic acid
(NDGA)
Catalog No.: PC-24005Not For Human Use, Lab Use Only.
Nordihydroguaiaretic acid (NDGA) is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor, also suppresses NOD-like receptor family pyrin domain containing 3 (Nlrp3) inflammasome activation and subsequent hepatic pyroptosis, inhibit ferroptosis in nucleus pulposus cells (NPCs).
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| 100 mg | $58 | In stock | |
| 500 mg | $98 | In stock | |
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Nordihydroguaiaretic acid (NDGA) is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor, also suppresses NOD-like receptor family pyrin domain containing 3 (Nlrp3) inflammasome activation and subsequent hepatic pyroptosis, inhibit ferroptosis in nucleus pulposus cells (NPCs).
Physicochemical Properties
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M.Wt
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302.37
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Formula
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C18H22O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4,4'-(2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)
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References
1. Zhang Y, et al. Int Immunopharmacol. 2024 Dec 25;143(Pt 3):113590.
2. Zhu S, et al. J Hepatol. 2025 Jan 22:S0168-8278(25)00014-5.
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