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Norendoxifen

Chemical Structure : Norendoxifen

CAS No.: 1217237-98-3

Norendoxifen

Catalog No.: PC-70132Not For Human Use, Lab Use Only.

Norendoxifen is an active metabolite of the selective estrogen receptor modulator (SERM) tamoxifen.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Norendoxifen is an active metabolite of the selective estrogen receptor modulator (SERM) tamoxifen.
    Norendoxifen is not a SERM, and instead has been found to act as a potent and selective competitive inhibitor of aromatase with Ki of 35 nM.

    Physicochemical Properties

    M.Wt 359.47
    Formula C24H25NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

    References

    1. Lu WJ, et al. Breast Cancer Res Treat. 2012 May;133(1):99-109.

    2. Lv W, et al. J Med Chem. 2015 Mar 26;58(6):2623-48.

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