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Chemical Structure : Notum inhibitor 23dd
Catalog No.: PC-72823Not For Human Use, Lab Use Only.
Notum inhibitor 23dd is a potent, brain-penetrant and orally active inhibitor of Notum carboxylesterase activity with IC50 of 18 nM.
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Notum inhibitor 23dd is a potent, brain-penetrant and orally active inhibitor of Notum carboxylesterase activity with IC50 of 18 nM.
Notum inhibitor 23dd demonstrated good plasma exposure and partial blood–brain barrier penetration after oral administration in mouse.
Notum inhibitor 23dd is a new chemical tool for exploring the role of Notum-mediated regulation of Wnt signaling.
| M.Wt | 264.588 | |
| Formula | C9H4ClF3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mahy W, et al. J Med Chem. 2020 Nov 12;63(21):12942-12956.
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