Notum inhibitor 23dd

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Chemical Structure : Notum inhibitor 23dd

Catalog No.: PC-72823Not For Human Use, Lab Use Only.

Notum inhibitor 23dd is a potent, brain-penetrant and orally active inhibitor of Notum carboxylesterase activity with IC50 of 18 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Notum inhibitor 23dd is a potent, brain-penetrant and orally active inhibitor of Notum carboxylesterase activity with IC50 of 18 nM.
Notum inhibitor 23dd demonstrated good plasma exposure and partial blood–brain barrier penetration after oral administration in mouse.
Notum inhibitor 23dd is a new chemical tool for exploring the role of Notum-mediated regulation of Wnt signaling.

Physicochemical Properties

M.Wt	264.588
Formula	C9H4ClF3N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-chloro-3-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one

References

1. Mahy W, et al. J Med Chem. 2020 Nov 12;63(21):12942-12956.

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