Notum inhibitor 4d

Chemical Structure : Notum inhibitor 4d

Catalog No.: PC-72822Not For Human Use, Lab Use Only.

Notum inhibitor 4d is a highly potent inhibitor of Notum with IC50 of <10 nM, restores Wnt/β-catenin signaling in cell-based models.

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Biological Activity

Notum inhibitor 4d is a highly potent inhibitor of Notum with IC50 of <10 nM, restores Wnt/β-catenin signaling in cell-based models.
Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity.

Physicochemical Properties

M.Wt	258.299
Formula	C12H10N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[(4-Methylphenyl)thio]-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one

References

1. Steadman D, et al. J Med Chem. 2022 Jan 13;65(1):562-578.

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