Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Nucleozin
CAS No.: 341001-38-5
Catalog No.: PC-45819Not For Human Use, Lab Use Only.
A small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $390.4 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation; inhibits infection of MDCK cells by viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 of 0.069 uM, 0.16 uM and 0.33 uM in PRA, respectively; protects mice challenged with lethal doses of avian influenza A H5N1; also targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection.
Influenza
Preclinical
| M.Wt | 426.853 | |
| Formula | C21H19ClN4O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: 28.66 mg/mL (Need ultrasonic) |
|
| Chemical Name/SMILES |
Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- |
|
1. Kao RY, et al. Nat Biotechnol. 2010 Jun;28(6):600-5.
2. Amorim MJ, et al. J Virol. 2013 Apr;87(8):4694-703.
3. Su CY, et al. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19151-6.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
