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Chemical Structure : O-1602
CAS No.: 317321-41-8
Catalog No.: PC-35196Not For Human Use, Lab Use Only.
O-1602 (O1602) is an atypical cannabinoid, potent and selective agonist of GPR55 cannabinoid receptor with EC50 of 13 nM, shows no significant activity for CB1 and CB2 receptors (EC50>30 uM).
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O-1602 (O1602) is an atypical cannabinoid, potent and selective agonist of GPR55 cannabinoid receptor with EC50 of 13 nM, shows no significant activity for CB1 and CB2 receptors (EC50>30 uM).
O-1602 stimulates GPR55-dependent GTPgammaS activity with EC50 of <2 nM.
O-1602 inhibits mouse osteoclast formation in vitro, stimulates mouse and human osteoclast polarization and resorption in vitro and caused activation of Rho and ERK1/2, affects bone mass in vivo.
O-1602 protects against experimental colitis and inhibits neutrophil recruitment.
| M.Wt | 258.36 | |
| Formula | C17H22O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-Methyl-4-[(1R,6R)-3-methyl-6-(1-cyclohexen-1-yl]-1,3-benzenediol |
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1. Johns DG, et al. Br J Pharmacol. 2007 Nov;152(5):825-31.
2. Whyte LS, et al. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16511-6.
3. Schuelert N, et al. Neurosci Lett. 2011 Aug 1;500(1):72-6.
4. Schicho R, et al. Inflamm Bowel Dis. 2011 Aug;17(8):1651-64.
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