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OAT-1746

Chemical Structure : OAT-1746

CAS No.: 2146132-73-0

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OAT-1746 (OAT1746;OATD-02)

Catalog No.: PC-61993Not For Human Use, Lab Use Only.

OAT-1746 (OATD-02) is a novel potent, selective, orally active inhibitors of Arginase 1 and 2 (ARG1/2) with IC50 of 20 nM and 39 nM for hARG1 and hARG2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OAT-1746 (OATD-02) is a novel potent, selective, orally active inhibitors of Arginase 1 and 2 (ARG1/2) with IC50 of 20 nM and 39 nM for hARG1 and hARG2, respectively.
    OAT-1746 (OATD-02) reverses the ARG1-inhibited proliferation of human and murine T cells and restored CD3ζ expression in ex vivo assays.
    OAT-1746 (OATD-02) demonstrates antitumor activity alone or in combination with checkpoint inhibitors and gemcitabine in vivo.

    Physicochemical Properties

    M.Wt 272.15
    Formula C12H25BN2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2S,5R)-1-amino-5-(2-boronoethyl)-2-((dimethylamino)methyl)cyclohexane-1-carboxylic acid

    References

    1. Borek B, et al. Mol Cancer Ther. 2023 Mar 20:MCT-22-0721.

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