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OAT-177

Chemical Structure : OAT-177

CAS No.: 1799548-33-6

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OAT-177 (OAT177)

Catalog No.: PC-62540Not For Human Use, Lab Use Only.

OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1.
    OAT-177 shows significant anti-inflammatory efficacy in HDM-induced allergic airway inflammation in mice at 30 mg/kg po.
    OAT-177 reduces inflammatory cell influx in the BALF and total IgE concentration in plasma.

    Physicochemical Properties

    M.Wt 376.933
    Formula C19H29ClN6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(5-amino-1H-1,2,4-triazol-3-yl)-N-(4-chlorophenethyl)-N-isobutylpiperidin-4-amine

    References

    1. Mazur M, et al. J Med Chem. 2018 Feb 8;61(3):695-710.

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