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OAT-2068

Chemical Structure : OAT-2068

CAS No.: 2221950-65-6

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OAT-2068 (OAT2068)

Catalog No.: PC-62539Not For Human Use, Lab Use Only.

OAT-2068 is a potent, selective, orally bioavailable inhibitor of mouse chitotriosidase (mCHIT1) with IC50 of 29 nM, 143-fold selectivity over mAMCase.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OAT-2068 is a potent, selective, orally bioavailable inhibitor of mouse chitotriosidase (mCHIT1) with IC50 of 29 nM, 143-fold selectivity over mAMCase.
OAT-2068 exhibits excellent pharmacokinetic profile and is an ideal and unique tool for studying the role of CHIT1 in biological models.

Physicochemical Properties

M.Wt 446.04
Formula C23H36ClN7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-((2S,5S)-2-(4-chlorobenzyl)-4-isobutyl-5-methylpiperazin-1-yl)piperidin-1-yl)-1H-1,2,4-triazol-5-amine

References

1. Mazur M, et al. Bioorg Med Chem Lett. 2017 Dec 22. pii: S0960-894X(17)31221-0.

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