OAT-870 | Chitinase inhibitor | Probechem Biochemicals

Chemical Structure : OAT-870

OAT-870 (OAT 870)

Catalog No.: PC-21913Not For Human Use, Lab Use Only.

OAT-870 is a potent dual AMCase and CHIT1 inhibitor with IC50 of 48/74 nM (human/ mouse CHIT1) and 22/30 nM (h/mAMCase).

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Biological Activity

OAT-870 is a potent dual AMCase and CHIT1 inhibitor with IC50 of 48/74 nM (human/ mouse CHIT1) and 22/30 nM (h/mAMCase).
OAT-870 displays good in vitro activity for both human and murine chitinases.
OAT-870 exhibits significant anti-inflammatory effect in HDM-induced airway inflammation model in mice.

Physicochemical Properties

M.Wt	376.89
Formula	C18H25ClN6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(4-(3-(4-chlorobenzyl)morpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine

References

1. Marzena Mazur, et al. Int J Mol Sci. 2021 Jul; 22(13): 6966.

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OAT-870 (OAT 870)

Biological Activity

Physicochemical Properties

References

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