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Chemical Structure : OBR-5-340
Catalog No.: PC-21696Not For Human Use, Lab Use Only.
OBR-5-340 is a potent, orally bioavailable inhibitor targeting capsid of Rhino- and Enteroviruses,exhibits broad-spectrum antiviral activity against of enteroviruses and rhinoviruses.
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OBR-5-340 is a potent, orally bioavailable inhibitor targeting capsid of Rhino- and Enteroviruses,exhibits broad-spectrum antiviral activity against of enteroviruses and rhinoviruses.
OBR-5-340 strongly inhibits the cytopathic effect of the pleconaril-resistant CVB3 Nancy (L1092[4c]) as well as pleconaril-susceptible CVB3 97927 (I1092) with IC50 values of 0.16 and 1.05 μM, respectively.
OBR-5-340 shows highest activities against high-level pleconaril-resistant viruses including RV5, RV42, RV44, RV48, and RV69 with IC50 values of 0.04 to 0.64 uM.
OBR-5-340 exerts a strong antiviral effect in a model of CVB3-induced chronic myocarditis in NMRI mice.
OBR-5-340 inhibits a broad-spectrum of EVs and RVs, helps to overcome the resistance of known capsid inhibitors, and does not exert an effect on relevant cytochrome isoforms.
| M.Wt | 370.34 | |
| Formula | C18H13F3N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Makarov VA, et al. ChemMedChem. 2015 Oct;10(10):1629-34.
2. Wald J, et al. Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19109-19115.
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