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ODQ

Chemical Structure : ODQ

CAS No.: 41443-28-1

ODQ (sGC inhibitor ODQ)

Catalog No.: PC-63138Not For Human Use, Lab Use Only.

ODQ (sGC inhibitor ODQ) is a potent, selective, irreversible inhibitor of sGC (soluble guanylyl cyclase).

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Biological Activity

ODQ (sGC inhibitor ODQ) is a potent, selective, irreversible inhibitor of sGC (soluble guanylyl cyclase).
ODQ inhibits the elevation of cGMP induced by the NO donor S-nitroso-DL-penicillamine in human platelets and rat vascular smooth muscle (IC50 = 10-60 nM and <10 nM, respectively).
ODQ has no effect on NO synthase.

Physicochemical Properties

M.Wt 187.158
Formula C9H5N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

References

1. Moro MA, et al. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1480-5.

2. Cellek S, et al. Br J Pharmacol. 1996 May;118(1):137-40.

3. Schrammel A, et al. Mol Pharmacol. 1996 Jul;50(1):1-5.

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