Catalog No.: PC-61649Not For Human Use, Lab Use Only.
ONC201 (Dordaviprone, TIC10, ONC-201) is a potent, orally active, and brain-permeable small molecule that transcriptionally induces TRAIL in a p53-independent manner, a selective dopamine receptor D2 (DRD2) antagonist.
ONC201 (Dordaviprone, TIC10, ONC-201) is a potent, orally active, and brain-permeable small molecule that transcriptionally induces TRAIL in a p53-independent manner, a selective dopamine receptor D2 (DRD2) antagonist.
ONC201 induces a sustained up-regulation of TRAIL in tumors and normal cells, inactivates kinases Akt and ERK, leading to the translocation of Foxo3a into the nucleus.
ONC201 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.
