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ONO-1301

Chemical Structure : ONO-1301

CAS No.: 176391-41-6

ONO-1301 (ONO 1301, ONO1301)

Catalog No.: PC-60721Not For Human Use, Lab Use Only.

ONO-1301 is a stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ONO-1301 is a stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.
ONO-1301 suppresses the elevation of protein excretion into urine in rats, attenuates the development of bleomycin-induced pulmonary fibrosis and improves survival in bleomycin mice.

Physicochemical Properties

M.Wt 428.488
Formula C26H24N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

[7,8-dihydro-5-[(E)-[[a-(3-pyridyl)benzylidene]-aminooxy]ethyl]-1 -naphtyloxy]acetic acid

References

1. Hayashi K, et al. Jpn J Pharmacol. 1997 Jan;73(1):73-82.

2. Rudd JA, et al. Br J Pharmacol. 2000 Feb;129(4):782-90.

3. Chow KB, et al. Br J Pharmacol. 2001 Dec;134(7):1375-84.

4. Murakami S, et al. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L59-65.

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