Chemical Structure : ONO-2920632
CAS No.:
2230296-66-7
ONO-2920632
(VU6011887)
Catalog No.: PC-24079Not For Human Use, Lab Use Only.
ONO-2920632 (VU6011887) is a potent, highly selective and CNS penetrant TREK-2 (TWIK-related K+ channel 2, K2P10.1) activator with EC50 of 0.3 uM (Emax=184%).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ONO-2920632 (VU6011887) is a potent, highly selective and CNS penetrant TREK-2 (TWIK-related K+ channel 2, K2P10.1) activator with EC50 of 0.3 uM (Emax=184%).
ONO-2920632 shows selectivity versus the other K2P channels (>91-fold selective vs TASK1, TASK2, TASK3, TRAAK, TWIK2, and 31-fold selective vs TRESK) and no significant activity in a large ancillary pharmacology panel.
ONO-2920632 (VU6011887) displayed robust, dose dependent efficacy when dosed orally in a mouse pain model (acetic acid writhing assay).
Physicochemical Properties
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M.Wt
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354.26
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Formula
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C15H10F4N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-fluoro-4-(trifluoromethoxy)benzyl)-[1,2,4]triazolo[1,5-a]pyridine-6-carboxamide
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References
1. Yashiro K, et al. ACS Chem Neurosci. 2025 Feb 21. doi: 10.1021/acschemneuro.5c00032.
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