Catalog No.: PC-61421Not For Human Use, Lab Use Only.
ONO-5334 is a potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively.
ONO-5334 is a potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively.
ONO-5334 shows less or no potentcy for human cathepsin S/L/B/C (Ki=0.83/1.7/32/2500 nM).
ONO-5334 inhibits human osteoclasts bone resorption in vitro at a concentration more than 100 fold lower than that of alendronate.
ONO-5334 reduces plasma calcium level increased by PTHrP in thyroparathyroidectomized rats, decreases serum and urine C-telopeptide of type I collagen level.
ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with EC50 of 500 nM.
