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ONO-7300243

Chemical Structure : ONO-7300243

CAS No.: 638132-34-0

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ONO-7300243 (ONO7300243;ONO 7300243)

Catalog No.: PC-42284Not For Human Use, Lab Use Only.

ONO7300243 is a novel potent, selective, orally available lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 0.16 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ONO7300243 is a novel potent, selective, orally available lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 0.16 uM.
ONO7300243 exhibits good selectivity (>50-fold) toward LPA1over LPA2; shows good efficacy in vivo, reduces intraurethral pressure in rats without affecting the blood pressure (30mg/kg. p.o.).

Physicochemical Properties

M.Wt 461.54944
Formula C28H31NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzeneacetic acid, 4-[[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl]-

References

1. Terakado M, et al. ACS Med Chem Lett. 2016 Aug 19;7(10):913-918.

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