Catalog No.: PC-73130Not For Human Use, Lab Use Only.
ONO-7475 (Tamnorzatinib) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations.
ONO-7475 (Tamnorzatinib) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations.
ONO-7475 sensitizes AXL-expressing EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib.
ONO-7475 suppresses the emergence and maintenance of EGFR-TKI-tolerant cells, suppresses the phosphorylation of AKT, p70S6K, ERK, as well as EGFR.
Combination therapy of ONO-7475 and osimertinib delays regrowth of cell line-derived xenograft tumors.
Osimertinib-acquired resistant cells are insensitive to combined therapy with osimertinib and ONO-7475.
