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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Potassium Channel-ONO-7927846
ONO-7927846

Chemical Structure : ONO-7927846

CAS No.: 2640753-27-9

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ONO-7927846 (VU6024391)

Catalog No.: PC-25626Not For Human Use, Lab Use Only.

ONO-7927846 (VU6024391) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 110 nM and 290 nM for human TREK-1 and TREK-2 in thallium flux assays respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ONO-7927846 (VU6024391) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 110 nM and 290 nM for human TREK-1 and TREK-2 in thallium flux assays respectively.
ONO-7927846 shows no significant activity for TASK-1, TASK-2, THIK-1 and TRESK.
ONO-7927846 displayed robust efficacy in an MK-801 challenge rat NOR paradigm, with MED of 0.3 mg/kg.

Physicochemical Properties

M.Wt 497.93
Formula C25H22ClF2N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((3R,4R)-1-Acetyl-3-fluoropiperidin-4-yl)-4-chloro-N-(5-((4-fluorophenyl)ethynyl)-3-methylpyridin-2-yl)-1H-pyrazole-5-carboxamide

References

1. Tanaka M, et al. J Med Chem. 2025 Oct 17. doi: 10.1021/acs.jmedchem.5c02535.

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