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Chemical Structure : ONO-8130
CAS No.: 459841-96-4
Catalog No.: PC-38519Not For Human Use, Lab Use Only.
ONO-8130 is a selective, orally bioavailable antagonist of prostaglandin E2 (PGE2) receptor EP1 with Ki value of 1.9 nM, >1,000-fold selectivity for EP1 over other EP receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $788 | In stock | |
| 1 g | Get quote |
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ONO-8130 is a selective, orally bioavailable antagonist of prostaglandin E2 (PGE2) receptor EP1 with Ki value of 1.9 nM, >1,000-fold selectivity for EP1 over other EP receptors.
ONO-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner.
Oral ONO-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain.
| M.Wt | 500.6 | |
| Formula | C25H28N2O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[[[2,3-dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-inden-5-yl]oxy]methyl]-benzoic acid |
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1. Miki T, et al. Pain. 2011 Jun;152(6):1373-1381.
2. Säfholm J, et al. Br J Pharmacol. 2013 Feb;168(4):794-806.
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