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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Potassium Channel-ONO-9517601
ONO-9517601

Chemical Structure : ONO-9517601

CAS No.: 2640753-22-4

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ONO-9517601 (VU6022856)

Catalog No.: PC-25625Not For Human Use, Lab Use Only.

ONO-9517601 (VU6022856) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 67 nM and 230 nM for human TREK-1 and TREK-2 in thallium flux assays respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ONO-9517601 (VU6022856) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 67 nM and 230 nM for human TREK-1 and TREK-2 in thallium flux assays respectively.
ONO-9517601 shows no significant activity for TASK-1, TASK-2, THIK-1 and TRESK.
ONO-9517601 displayed robust efficacy in an MK-801 challenge rat NOR paradigm, with MED of 1 mg/kg.

Physicochemical Properties

M.Wt 461.95
Formula C25H24ClN5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(1-Acetylpiperidin-4-yl)-4-chloro-N-(3-methyl-5-(phenylethynyl)pyridin-2-yl)-1H-pyrazole-5-carboxamide

References

1. Tanaka M, et al. J Med Chem. 2025 Oct 17. doi: 10.1021/acs.jmedchem.5c02535.

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