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Chemical Structure : ONO-AE3-208
CAS No.: 402473-54-5
Catalog No.: PC-45896Not For Human Use, Lab Use Only.
ONO-AE3-208 (AE3-208) is a potent, selective EP4 receptor antagonist with Ki of 1.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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ONO-AE3-208 (AE3-208) is a potent, selective EP4 receptor antagonist with Ki of 1.3 nM.
ONO-AE3-208 displays less potently affects EP3, FP, and TP receptors (Ki=30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors.
ONO-AE3-208 ameliorates severe colitis normally induced with 7% DSS, suppresses cell invasion, migration, and metastasis of prostate cancer both in vivo and in vitro.
| M.Wt | 404.4335 | |
| Formula | C24H21FN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]- |
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1. Kabashima K, et al. J Clin Invest. 2002 Apr;109(7):883-93.
2. Ma X, et al. Cancer Res. 2006 Mar 15;66(6):2923-7.
3. Esaki Y, et al. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12233-8.
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