ONO-TR-772 (VU6018042)

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Chemical Structure : ONO-TR-772

Catalog No.: PC-24597Not For Human Use, Lab Use Only.

ONO-TR-772 (VU6018042) is a potent, selective and CNS penetrant TREK (TWIK related K+ channel) inhibitor with IC50 of 15 nM (TREK-1, human manual patch clamp (MPC)), equipotent with TREK-2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ONO-TR-772 (VU6018042) is a potent, selective and CNS penetrant TREK (TWIK related K+ channel) inhibitor with IC50 of 15 nM (TREK-1, human manual patch clamp (MPC)), equipotent with TREK-2.
ONO-TR-772 displays >67-fold selective over other K2P channels (TASK-3, TRESK, TWIK-2, TRAAK, TASK-1, TASK-2).
ONO-TR-772 (VU6018042) demonstrated robust efficacy in an MK-801 challenge NOR paradigm, with an MED of 10 mg/kg.

Physicochemical Properties

M.Wt	479.94
Formula	C26H23ClFN3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-Butyl (4-chloro-3-((5-((4-fluorophenyl)ethynyl)-3-methylpyridin-2-yl)carbamoyl)phenyl)carbamate

References

1. Motoyuki Tanaka, et al. ACS Med Chem Lett. 2025 Apr 28;16(5):896-901.

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