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Chemical Structure : OR0642
Catalog No.: PC-22531Not For Human Use, Lab Use Only.
OR0642 is a highly potent, specific deoxycytidine kinase (dCK) inhibitor with IC50 of 2.2 nM.
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OR0642 is a highly potent, specific deoxycytidine kinase (dCK) inhibitor with IC50 of 2.2 nM.
OR0642 is more than 1000 times more potent than its initial parent compound, masitinib.
OR0642 in combination with a physiological inhibitor of the de novo pathway doubled the survival rate in a human T-cell acute lymphoblastic leukemia patient-derived xenograft mouse model.
| M.Wt | 646.75 | |
| Formula | C29H33F3N8O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Magali Saez-Ayala, et al. Nat Commun. 2023 May 29;14(1):3079.
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