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OR0642

Chemical Structure : OR0642

CAS No.: 2953693-22-4

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OR0642 (OR-0642)

Catalog No.: PC-22531Not For Human Use, Lab Use Only.

OR0642 is a highly potent, specific deoxycytidine kinase (dCK) inhibitor with IC50 of 2.2 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

OR0642 is a highly potent, specific deoxycytidine kinase (dCK) inhibitor with IC50 of 2.2 nM.
OR0642 is more than 1000 times more potent than its initial parent compound, masitinib.
OR0642 in combination with a physiological inhibitor of the de novo pathway doubled the survival rate in a human T-cell acute lymphoblastic leukemia patient-derived xenograft mouse model.

Physicochemical Properties

M.Wt 646.75
Formula C29H33F3N8O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-((4-methyl-4'-((4-methylpiperazin-1-yl)sulfonyl)-2'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)(propyl)amino)thiazol-4-yl)pyrimidine-4,6-diamine

References

1. Magali Saez-Ayala, et al. Nat Commun. 2023 May 29;14(1):3079.

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