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OR486

Chemical Structure : OR486

CAS No.: 7659-29-2

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OR486 (OR-486, 3,5-Dinitrocatechol)

Catalog No.: PC-23347Not For Human Use, Lab Use Only.

OR486 (3,5-Dinitrocatechol, OR-486) is a potent, selective catechol-O-methyltransferase (COMT) inhibitor with IC50 of 12 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OR486 (3,5-Dinitrocatechol, OR-486) is a potent, selective catechol-O-methyltransferase (COMT) inhibitor with IC50 of 12 nM.
OR486 does not inhibit tyrosine hydroxylase, dopamine-beta-hydroxylase, dopa-decarboxylase and monoamine oxidase forms A and B.
OR486 is more effective in reducing the formation of 3-O-methyldopa from levodopa than was the levodopa-carbidopa treatment alone.

Physicochemical Properties

M.Wt 200.11
Formula C6H4N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,5-Dinitrocatechol

References

1. Nissinen E, et al. Eur J Pharmacol. 1988 Aug 24;153(2-3):263-9.

2. Werner P, et al. Brain Res. 2001 Mar 2;893(1-2):278-81.

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