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Chemical Structure : OR486
CAS No.: 7659-29-2
Catalog No.: PC-23347Not For Human Use, Lab Use Only.
OR486 (3,5-Dinitrocatechol, OR-486) is a potent, selective catechol-O-methyltransferase (COMT) inhibitor with IC50 of 12 nM.
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|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
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OR486 (3,5-Dinitrocatechol, OR-486) is a potent, selective catechol-O-methyltransferase (COMT) inhibitor with IC50 of 12 nM.
OR486 does not inhibit tyrosine hydroxylase, dopamine-beta-hydroxylase, dopa-decarboxylase and monoamine oxidase forms A and B.
OR486 is more effective in reducing the formation of 3-O-methyldopa from levodopa than was the levodopa-carbidopa treatment alone.
| M.Wt | 200.11 | |
| Formula | C6H4N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3,5-Dinitrocatechol |
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1. Nissinen E, et al. Eur J Pharmacol. 1988 Aug 24;153(2-3):263-9.
2. Werner P, et al. Brain Res. 2001 Mar 2;893(1-2):278-81.
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